General Information

  • ID:  hor001064
  • Uniprot ID:  NA
  • Protein name:  CalliFMRFamide 4
  • Gene name:  NA
  • Organism:  Haemonchus contortus
  • Family:  FMRFamide related peptide family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  KPNQDFMRF
  • Length:  9
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T9 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Caused a slow relaxation of body wall muscle
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001064_AF2.pdbhor001064_ESM.pdb

Physical Information

Mass: 132523 Formula: C53H79N15O14S
Absent amino acids: ACEGHILSTVWY Common amino acids: F
pI: 9.69 Basic residues: 2
Polar residues: 1 Hydrophobic residues: 2
Hydrophobicity: -144.44 Boman Index: -3306
Half-Life: 1.3 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 0
Instability Index: -322.22 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  15111097
  • Title:  Arthropod FMRFamide-related Peptides Modulate Muscle Activity in Helminths